During brood-rearing, greater sage-grouse (Centrocercus urophasianus; hereafter, sage-grouse) utilize heterogeneous upland meadows that hold moisture and support important food resources. Brood-rearing habitat may become fragmented with widespread habitat loss across the range due to invasion of annual grasses, conifer expansion, and anthropogenic development. We sought to understand impacts of these stressors on sage-grouse brood habitat as these disturbances threaten long-term productivity and population viability. An 11-year study of brood-rearing habitat at 12 sites across the Great Basin demonstrated that increasing annual grass negated positive effects of burned areas on brood survival when annual grass was dominant, highlighting the importance of heterogeneous vegetation communities for sage-grouse broods. Brood-rearing sage-grouse from 10 sites within the Bi-State Distinct Population Segment likely face trade-offs, wherein the need for forage-rich mesic resources at higher elevations may necessitate weakened avoidance of conifers, with consequences for survival. The importance of mesic resources, especially during dry years, was also evident within the Long Valley subpopulation of the Bi-State, where brood survival was positively influenced by the availability and condition of managed mesic resources. Taken together, these findings shed light on the influences of altered landscapes on sage-grouse brood-rearing habitat. Information is preliminary and provided for best timely science.