The giant gartersnake (Thamnophis gigas), an imperiled snake species native to California's Central Valley, has suffered dramatic declines due to >90% loss in historical wetland habitats from agriculture conversion. Extant populations of giant gartersnakes now inhabit highly-managed agriculture floodplains (rice fields) in the Sacramento Valley. Previous studies indicate that survival of the snakes is correlated with availability of rice agriculture; thus rice agriculture currently supports the snake population. It is increasingly important to better understand how to optimize these habitats for snakes, and to explore whether current agricultural practices are negatively impacting the snake in any way. We aim to identify other inhibitors of survival that there are no current data for, specifically, the presence of organochlorine pesticides. Organochlorine pesticides including the DDX group have been detected in biota in this region yet have not been examined in giant gartersnakes despite being in the class of endocrine disrupting chemicals. The high trophic position of the giant gartersnake combined with longevity, and their site-fidelity to areas often maintained by agrochemicals, increase their likelihood for pesticide accumulation. Given their diminishing numbers and listed status, it is crucial to identify if agrochemicals are contributing to inhibited reproduction and survival.