The Southern Sierra Nevada Distinct Population Segment of fisher (Pekania pennanti) was listed as federally endangered in 2020. Given the dramatic changes in habitat and wildfire activity that have occurred in the Sierra Nevada region over the past decade, understanding the causal factors behind demographic rates is critical for the species’ conservation. Between 2007 and 2017, two large research efforts collected telemetry data on nearly 300 fishers on the Sierra National Forest. To better understand factors driving fisher survival, we revisited this dataset and compared it to several recently developed time-series datasets of habitat change and management activity. We examined the relationships between individual survival and physiology, landscape composition and configuration, and human activities such as hazardous fuel reduction and illegal marijuana cultivation at the home range scale. This information will be crucial in helping to balance fisher conservation with forest restoration work in the new Sierra Nevada landscape.