Spotted skunks (Spilogale spp.) are small-bodied carnivores that inhabit diverse biogeographic regions and have lived in North America since the early Pliocene. Spilogale likely diverged in refugial locations along the southern and western United States and Northern Mexico, expanding their range northward and eastward during interglacial periods. The genus currently comprises four recognized spotted skunk species: western (S. gracilis), eastern (S. putorius), southern (S. angustifrons), and pygmy (S. pygmaea; Dragoo et al. 2009). Recent genetic studies suggest elevating several subspecies to species level, but phylogenetic relationships among these lineages remain unclear. To further investigate the evolutionary history of spotted skunks, we sequenced 17 whole genomes from skunks collected in Mexico and throughout the United States to estimate the order and timing of broad-scale demographic events. Additionally, we investigated different demographic hypotheses using bioclimate modeling in conjunction with sequence data. Our findings provide new insights into the evolutionary dynamics and historical biogeography of Spilogale, shedding light on the processes that shaped their current diversity and distributions across North America.