Feral cats (Felis catus) are among the world’s most damaging invasive species, contributing to global species declines. In Hawai‘i, cats have contributed to population declines of endangered ground-nesting seabirds, native forest birds, and marine mammals through Taxoplasma gondii transmission. No statewide assessment has examined how ecological and human factors shape their distribution and behavior. This study identifies key environmental and human drivers of cat occupancy and activity across Kaua‘i, O‘ahu, Maui, and Hawai‘i Island to guide management. From 2016–2023, game cameras were deployed at 194 randomly stratified sites representing diverse ecosystems across elevational and climatic gradients. Over 4,600 trap nights produced 1,349 confirmed detections. Occupancy was calculated using Bayesian methods, accounting for imperfect detection and testing the influence of land cover, vegetation height, elevation, precipitation, and distance to urban areas. Activity patterns were analyzed using 24-hour kernel density estimates derived from timestamped detections. Occupancy was highest near urban areas and declined with increasing elevation, rainfall, and vegetation height. However, cats were still detected in remote and high elevation habitats. Activity remained largely nocturnal, with greater nocturnality in remote areas consistent with increased hunting reliance. Results will inform targeted management and improve conservation for Hawai‘i’s native fauna.