Environmental and anthropogenic landscape-level alterations are forcing predators, prey, livestock, and humans to share space in novel ways that increase the potential for conflict. Following their broad-scale extirpation, wolves in California are returning to novel, human-use landscapes that are being increasingly affected by environmental disturbances. Herein, we analyzed habitat selection by wolves (n = 15) in four packs between 2017-2025 to understand the environmental drivers of wolf space use and response to disturbance. We modeled seasonal resource selection functions to analyze preference for habitat types and individual variation in pack and wolf behavior related to prey density, wildfire intensity, and rangelands. Our preliminary findings indicate that wolves selected for areas of higher prey densities, but responded differently to native and domestic prey. We also found that wolves had variable responses to both environmental and anthropogenic landscape alterations and response to disturbance was mediated by prey density. With the largest human population in the US and livestock consistently intermixed with native prey, wolves are returning to a very different California than they once may have known. Our results provide insight into how California wolves might respond to landscape alterations and thus, predict future patterns of recolonization.